Ameliorative Effect of Gallic Acid Against Sodium Fluoride-Induced Hypertension and Hepato-Renal Complications In Wistar Rats

  • Olufunke O Ola-Davies
Keywords: Sodium fluoride, Gallic acid, Hypertension, hepatotoxicity


Gallic acid (GA) derivatives occur naturally in plants and it has been reported to possess antioxidant properties against various diseases. Here, the ameliorative effects of GA on sodium fluoride (NaF) induced hypertension and hepatotoxicity was studied. Four groups of seven rats each were used in this study. Group A received distilled water (control), group B received NaF (300 ppm), groups C and D received NaF + GA (60 mg/kg) and NaF + GA (120 mg/kg) respectively through oral gavage, for 7 days. The results showed that NaF alone significantly increased systolic, diastolic and mean arterial blood pressure. Administration of NaF also significantly raised both renal and hepatic hydrogen peroxide (H2O2), malondialdehyde (MDA), protein carbonyl (PC), serum myeloperoxidase (MPO) and significantly decreased reduced glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase and glutathione-s-transferase (GST). However, GA co-administration with NaF reduced high blood pressure and markers of oxidative stress, improved antioxidant defence system. It also ameliorated structural changes in renal and hepatic tissue morphology. Our findings thus suggest that gallic acid is a potential drug candidate in the treatment of NaF induced hypertension and hepatotoxicity.


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